Mechanistic insights into the efficacy of cell penetrating peptide-based cancer vaccines
نویسندگان
چکیده
منابع مشابه
Mechanistic insights into reducing the weight of breast cancer.
The prevalence of obesity, an established epidemiologic risk factor for many cancers including breast cancer in postmenopausal women (1), has increased dramatically over the past 30 years (2). Particularly alarming are the increasing rates of obesity among children. Therefore, we can expect continuing increases in the rates of adult obesity and obesity-related cancers for many years to come unl...
متن کاملEvaluation of Cell Penetrating Peptide Delivery System on HPV16E7 Expression in Three Types of Cell Line
Background: The poor permeability of the plasma and nuclear membranes to DNA plasmids are two major barriers for the development of these therapeutic molecules. Therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. Objectives: The aim of this study was to investigate the in vitro delivery of plasmid DNA encoding HPV16 E7 gene...
متن کاملVenom-based peptide therapy: insights into anti-cancer mechanism
The 5-year relative survival rate of all types of cancer has increased significantly over the past three decades partly due to the targeted therapy. However, still there are many targeted therapy drugs could play a role only in a portion of cancer patients with specific molecular alternation. It is necessary to continue to develop new biological agents which could be used alone and/or in combin...
متن کاملMechanistic Insights into Cell Death Mediated by the P53 Family
Development of effective anti-cancer therapies continues to be a challenge due to genetic instability that promotes intra-tumoral molecular heterogeneity and subsequent adaptation to therapy. In this review, we briefly discuss the history of the p53 family (p53/p63/p73) and how regulatory circuits affect its function in promoting apoptotic cell death. In addition, we provide perspective on how ...
متن کاملMechanistic Insights into Hsp104 Potentiation.
Potentiated variants of Hsp104, a protein disaggregase from yeast, can dissolve protein aggregates connected to neurodegenerative diseases such as Parkinson disease and amyotrophic lateral sclerosis. However, the mechanisms underlying Hsp104 potentiation remain incompletely defined. Here, we establish that 2-3 subunits of the Hsp104 hexamer must bear an A503V potentiating mutation to elicit enh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2018
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-018-2785-0